Refers to the sixteenth century, especially in Italian culture.<br><br>Italian, literally "five hundred," it refers to the 1500s ? the sixteenth century. It is especially used to refer to Italian art of that century, the time of the High Renaissance and Mannerism.(pr. CHEEN-kw&#601;-CHAYN-toh)Examples of works from the Italian cinquecento: Sebastiano Mainardi (Italian, 1450-1513), Madonna and Child with Saint John and Three Angels, c. 1500, tempera on wood panel, 33 3/4 x 33 3/4 inches, Birmingham Museum of Art.